Mathematical Oncology: Could We Cure Cancer with Calculus?

Could We Cure Cancer with Calculus?

Cancer is one of the major causes of death in the world, particularly the developed world, second only to cardiovascular disease. Over 10 million people throughout the world died from cancer in 2020 i.e. globally, almost 1 in 6 (16-17%) deaths can be attributed to cancer. In the UK between 2022 and 2024, the number of deaths was around 170,000. The latest data from the World Health Organisation show that approximately 20 million new cases were recorded in 2022 with this figure expected to increase to 32.6 million by 2045. There are few individuals whose lives have not been touched either directly or indirectly by cancer.

While treatment for cancer is continually improving, alternative approaches can offer even greater insight into the complexity of the disease and its treatment. In this talk, we will present an overview of the contribution mathematical modelling is playing in the fight against cancer, and highlight recent multiscale modelling that is giving real insight into several key processes involved in solid tumour growth and progression. The development of quantitative, predictive models (based on sound biological/clinical evidence and underpinned and parameterised by biological/clinical data) has the potential to have a positive impact on patients suffering from the disease through improved clinical treatment and optimised personalised medicine.