Robert Kolker with Sasha Sagan and Joanna Rakoff: The Vanishing Family

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From the #1 New York Times bestselling author of Hidden Valley Road comes the heart-wrenching journey of a family facing an unthinkable destiny, whose flawed genetic code might hold the long-sought key to a cure for dementia.
In the idyllic American town of Pleasant Hills, Pennsylvania, there lived a family with nine siblings, the youngest a girl named Barb. As the older children headed off to college and started their lives, only Barb was home to see their beautiful, still-young mother fall under a gothic spell, changing into someone she didn’t recognize: withdrawn, neglectful, uncaring. Thus begins The Vanishing Family, journalist Robert Kolker’s superb follow-up to Hidden Valley Road (“Deeply compassionate and chilling,” wrote The Washington Post). This family, we learn, has a genetic mutation that causes dementia, but with an especially cruel twist. As early as their forties, formerly loving parents and hard-driving executives will lose their jobs, have affairs, take up drinking—shed all inhibitions and sense of responsibility—and become people their families hardly know. Their former personalities seem to vanish—and there is a fifty-fifty chance that it will happen to their children, too.
The Vanishing Family unfolds like a heartbreaking thriller as the siblings begin to realize that what happened to their mother is happening to them: first one, then two, three, four, and more begin to change. Sue, in search of a calling, finds her place in caring for the others. Barb sets out to find a cure. Alongside their story, Kolker weaves in the dramatic scientific fight against dementia; after decades of blind alleys, this this family’s rare form of FTD (frontotemporal dementia) might lead to a breakthrough in the prevention and treatment of all dementia—including the scourge of Alzheimer’s disease. Moving, intimate, unexpectedly hopeful and redemptive, The Vanishing Family is an enthralling narrative about one family’s fate, and a medical detective story that speaks to all of us who fear losing ourselves at the end.

Robert Kolker is a contributing writer at The New York Times Magazine and author of the #1 New York Times bestseller Hidden Valley Road, named an Oprah’s Book Club Pick, a New York Times Book Review Top 10 book of the year, a GQ Best Book of Literary Journalism of the 21st Century, and a Kirkus Reviews Best Nonfiction Book of the Century. His first book was Lost Girls, named a New York Times Notable Book and a Publishers Weekly Best Book of 2013.

Sasha Sagan’s essays and interviews on death, history, and ritual through a secular lens have appeared in The Cut, O the Oprah Magazine, Parents, Atmos and beyond. She is the author of the critically acclaimed book For Small Creatures Such As We and the host of the podcast Strange Customs. Sasha regularly speaks in the U.S. and abroad about the ways science can inform our traditions and expand our sense of wonder.

Joanna Rakoff is the author of the international bestselling memoir My Salinger Year and the bestselling novel A Fortunate Age. Rakoff’s books have been translated into twenty languages, and the film adaptation of My Salinger Year opened in theaters worldwide in 2021 and is now streaming. She has been the recipient of fellowships and residencies from MacDowell, Sewanee, Bread Loaf, Authors’ Guild, PEN and more and has taught at Columbia University, Brooklyn College, and Aspen Words. Her writing has appeared in The New York Times, The Guardian, O: The Oprah Magazine, Vogue, Elle, and elsewhere.

Brookline Booksmith, thriving in the heart of Coolidge Corner in Brookline, Massachusetts, since 1961, is one of New England’s premier independent bookstores. We offer a vast selection of books, ranging from current bestsellers to the most eclectic titles. We are also known for our beautiful and inspired gifts. Customers buy and sell gently used books in our treasured Used Book Cellar and enjoy our bountiful bargain book selection. We host award-winning events series (including our groundbreaking Transnational Literature Series), offering more than 300 author talks, community conversations, and book clubs annually. Find more at brooklinebooksmith.com!