GBMSDG October Meeting - Resolving the Organ-Dependent Secretome

Schedule

Tue Oct 21 2025 at 05:00 pm to 08:00 pm

UTC-04:00

Location

Immerse Cambridge: A Waters Innovation and Research Lab | Cambridge, MA

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Join us for our October meeting!
Dr. Smythers will present at the Waters Immerse site in Kendall Square on October 21st.
About this Event

Join us for the next Greater Boston Mass Spectrometry Discussion Group Event!

On October 21st, Dr. Amanda Smythers, from Harvard Medical School and the Dana-Farber Cancer Institute, will present on "Resolving the Organ-Dependent Secretome: A Mass Spectrometry Approach to Inter-Organ Communication."

📍 Location: Waters Immerse, 301 Binney St, Suite 102, Cambridge, MA 02142
đź“… Date: October 21st, 2025

GBMSDG events are a great opportunity to learn about new mass spectrometry applications and network with the local MS community.

Special thanks to EvoSep and Waters for sponsoring the food, beverages, and event space!


Event Photos
Event Photos

Presentation Details


Title: Resolving the Organ-Dependent Secretome: A Mass Spectrometry Approach to Inter-Organ Communication

Abstract: Exercise produces broad physiological benefits, yet the molecular messengers that coordinate these effects across organs remain poorly defined. To address this gap, we developed a novel mass spectrometry–based framework for high-resolution, quantitative analysis of organ-specific secretomes. This approach enables consistent detection and relative quantification of both soluble and vesicle-associated proteins released directly from individual tissues, allowing us to compare secretion patterns across organs and physiological states. Applying this framework to models of exercise and metabolic remodeling reveals striking tissue-specific signatures and dynamic shifts that point to coordinated inter-organ communication. Distinct changes in the secreted proteomes of muscle, adipose tissue, lung, and placenta highlight the complexity of systemic signaling networks and demonstrate the reproducibility and depth achievable with this workflow. By resolving extracellular proteomes consistently across diverse tissues, this method expands the reach of secretome proteomics and provides a powerful platform for studying inter-organ signaling in vivo.


Event Photos
Agenda

đź•‘: 05:00 PM
Registration and Introduction
đź•‘: 06:15 PM
Speaker: Dr. Amanda Smythers

Info: Presentation: Resolving the Organ-Dependent Secretome: A Mass Spectrometry Approach to Inter-Organ Communication


đź•‘: 07:00 PM - 08:00 PM
Networking Session
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Where is it happening?

Immerse Cambridge: A Waters Innovation and Research Lab, 301 Binney Street, Cambridge, United States

Event Location & Nearby Stays:

Tickets

USD 8.24 to USD 12.51

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