Explore MeRGE: the Metrum Research Group Ecosystem

Learning Objectives

• Identify the freely-available, open-source R packages developed by MetrumRG to support traceable, reproducible, and scalable pharmacometric analyses
• Explore a reproducible pharmacometric analysis workflow

Topic Outline:

• Introduction to MetrumRG’s R package ecosystem
• Metrum Package Network (MPN)/pkgr: curated R package environment
• bbi/bbr: user-friendly interface for R and NONMEM®
• bbr.bayes: Bayesian modeling extension with Stan and NONMEM®
• yspec: data specifications, wrangling, documentation
• pmplots: exploratory and diagnostic plots
• pmforest: forest plots for pharmacometrics
• mrggsave: labeling, arranging, saving figures
• pmtables: tables for pharmacometrics
• lastdose: calculate last dose amount, time since previous doses
• Demonstration of package use for scalability, reproducibility in project set-up, data assembly, data exploration, model development & evaluation, simulation, and reporting
• Resources for additional learning

Requirements for Attendees

• All participants are required to bring a laptop and ensure access to either the Chrome or Safari web browser
• Knowledge and experience in PK modeling and the use of R

Host or Publisher Metrum Research Group, Inc.