Dana-Farber Center for BRCA & Related Genes Scientific Symposium

Dana-Farber Cancer Institute Center for BRCA and Related Genes Scientific Symposium is for clinicians, researchers, and anyone interested in learning more about BRCA 1/2 and related genes and exploring the latest research in a variety of cancer types affected by the mutations in the BRCA/HRR pathway genes.

This is a free event. Recordings of the presentations will be made available. Breakfast, lunch, and refreshments will be provided.

See below for agenda details. *Please note: Program changes/substitutions may be made without notice.

• Local, regional, national, and international HMS affiliated personnel
• Specialty physician researchers
• Clinicians

And providers who practice in the fields of:

• Oncology & Hematology
• Genetics
• Pathology
• Radiology & Nuclear Medicine
• Gastroenterology
• Internal Medicine
• Obstetrics & Gynecology
• Urology

Upon completion of this symposium, participants will be able to:

• Identify current and emerging approaches to early detection, screening, and prevention of hereditary breast, ovarian, pancreatic, and prostate cancers associated with mutations in the BRCA pathway
• Recognize and analyze the latest clinical and translational discoveries in the treatment of breast, ovarian, pancreatic, and prostate cancers associated with hereditary or acquired mutations in BRCA1/2 and related genes
• Discuss current ethical, legal, social, and diversity and inclusion issues related to carriers of BRCA1/2 and related genes

In support of improving patient care, Harvard Medical School is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Ph*rm*cy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

The Harvard Medical School designates this live activity for a maximum of 6.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

For the purpose of recertification, the American Academy of Nurse Practitioners Certification Board and American Nurses Credentialing Center accept AMA PRA Category 1 Credit™ issued by organizations accredited by the ACCME (Accreditation Council for Continuing Medical Education). We would also suggest that learners check with their state licensing board to ensure they accept reciprocity with AMA PRA Category 1 Credit™ for re-licensure.

The National Commission on Certification of Physician Assistants (NCCPA) states that AMA PRA Category 1 Credits™ are acceptable for continuing medical education requirements for recertification. We would also suggest that learners check with their state licensing board to ensure they accept reciprocity with AMA PRA Category 1 Credit™ for re-licensure.

The Royal College of Physicians and Surgeons of Canada recognizes conferences and workshops held outside of Canada that are developed by a university, academy, hospital, specialty society or college as accredited group learning activities.

The American Medical Association (AMA) has an agreement of mutual recognition of continuing medical education (CME) credit with the European Union of Medical Specialties (UEMS). Additional information regarding this agreement may be found here: https://www.uems.eu/areas-of-expertise/cme-cpd/eaccme

This course is designed to meet the following American Board of Medical Specialties (ABMS)/Accreditation Council for Graduate Medical Education (ACGME) competencies:

• Medical Knowledge
• Interpersonal and Communication Skills
• Professionalism
• Systems-Based Practice

This course is designed to meet the following Institute of Medicine Competencies:

• Work in Interdisciplinary Teams
• Utilize Informatics
• Apply Quality Improvement, Provide Patient-Centered Care
• Employ Evidence-Based Practice

In accord with the disclosure policy of the Medical School as well as standards set forth by the Accreditation Council for Continuing Medical Education (ACCME), course planners, speakers, and content reviewers have been asked to disclose any relationships they have to companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. In addition, faculty have been asked to list any off-label uses of pharmaceuticals and/or devices for investigational or non-FDA approved purposes that they plan to discuss

CME activities accredited by Harvard Medical School are offered solely for educational purposes and do not constitute any form of certification of competency. Practitioners should always consult additional sources of information and exercise their best professional judgement before making clinical decisions of any kind.

7:30 – 8:30 a.m. Registration and Breakfast, Yawkey 306-307

8:30 – 8:45 a.m. Opening Remarks, Panagiotis Konstantinopoulos, MD, PhD

8:45 – 9:45 a.m. "Bytes to bedside: Mutational signatures in BRCA1/BRCA2-deficiency and clinical updates” Serena Nik-Zainal, PhD

9:45 – 10:30 a.m. “How is prevention in the genes?” Fatima Karzai, MD

10:30 – 11:45 a.m. “Homologous recombination licensing role of BRCA1” Patrick Sung, DPhil

11:45 a.m. – 12:45 p.m. Lunch Break, Yawkey 306-307

12:45 – 1:30 p.m. “Therapeutic exploration of homologous recombination deficient in pancreatic cancer” Talia Golan, MD

1:30 – 2:15p.m. “Homologous recombination deficiency in prostate cancer: Implications for early detection and management of localized disease” Keyan Salari, MD, PhD

2:15 – 3:00 p.m. “Developing medicines to exploit novel and mature DDR targets” Ian Smith, MD

3:00 – 3:45 p.m. “Resistance to HRD targeting agents” Chris Lord, PhD

3:45– 4:00 p.m. Afternoon Break, Yawkey 306-307

4:00 – 4:45 p.m. “Leveraging epigenetics to address unmet needs in BRCAness ovarian cancer” Rugang Zhang, PhD

4:45– 5:15 p.m. “TITLE” Elizabeth K. Lee, MD

5:15 – 5:45 p.m. “Overcoming PARPi resistance by understanding BRCA1-dependent and BRCA1-independent HR” Yizhou He, PhD

5:45 p.m. Closing Remarks, Panagiotis Konstantinopoulos, MD, PhD

F or event related questions or special accommodations, please contact Isabel Donohoe: [email protected]

For questions related to Harvard Medical School Continuing Medical Education credits, please call (617) 384-8600, Mon-Fri, 9am to 5pm (ET) or by email at: [email protected].

Host or Publisher Dana-Farber Cancer Institute