Meta-research: a valuable tool to increase reproducibility

Dr Fiona Ramage is a postdoctoral researcher at CAMARADES (Collaborative Approach to Meta Analysis and Review of Animal Data from Experimental Studies), based in Edinburgh, Scotland. She started her PhD conducting mouse behaviour studies, but when confronted with the impacts of bias in her own research, switched to systematic review and meta-analysis methods applied to animal studies to address her research questions. She is currently involved in several large projects, with a focus on synthesising research on animal models of psychiatric illness and developing automated methods to accelerate the systematic review process. Additionally, she is keen to promote reproducible research more broadly, having founded and run ReproducibiliTea Dundee and currently being on the board for ReproducibiliTea Edinburgh, and participating in local initiatives to increase awareness around reproducibility and Open Science practices.

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Abstract

Meta-research is an emerging discipline involving the study of science itself. When used responsibly, it has the potential to improve the quality of scientific research and make it more reproducible via a number of different approaches. This talk will focus specifically on the benefits of systematic review and meta-analysis of animal studies. Using rigorous methodology and limiting bias, preclinical systematic reviews can offer new insights into a given research topic, inform experimental design, limit research waste, appraise the quality and reproducibility of existing research, and broadly encourage the adoption of better research practices.

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