IOCB Tony Holý Lecture: Morten Peter Meldal – The INAIC reaction

Name: IOCB Tony Holý Lecture: Morten Peter Meldal – The INAIC reaction
Start: 2025-02-25T10:00:00+01:00
Location: Flemingovo náměstí 542/2, 160 00 Prague, Czech Republic

Schedule

Tue, 25 Feb, 2025 at 10:00 am

UTC+01:00

Location

Flemingovo náměstí 542/2, 160 00 Prague, Czech Republic | Prague, PR

🗣️ We are looking forward to hosting Prof. Morten Peter Meldal (University of Copenhagen, Denmark) with an invited lecture "The INAIC reaction: An intramolecular click reaction".
"The CuAAC click reaction discovered in 2001 will be described, with mechanistic discussions and applications. The criteria for a click reaction will be outlined, and our INAIC click reaction will be presented. This reaction was discovered by NMR investigations of peptide aldehydes, which showed entropy-driven quantitative and highly selective reaction with backbone or sidechain amides in the peptide, to form reactive N-acyl iminium ions. These react with C, O, N or S nucleophiles in a tandem intramolecular reaction to form multiple heterocycles in a stereo- and enantioselective manner. A range of 3D-ligands for GPCRs was produced and assayed in a special gene eGFP reporter assay. Cells were attached to beads and mixed with a combinatorial split/mix library of putative agonist ligands. Active ligands were identified. A small library of clicked, macrocyclic peptides was produced and screened for MC4R activation."
Learn more at ► https://www.uochb.cz/en/event-calendar/332/tony-holy-lecture-morten-peter-meldal ⤵
Find the next #IOCBInvitedLecture ► uochb.cz/en/iocb-invited-lectures-2025 ⤵