Emergence of irreversible modulation in drug discovery

Name: Emergence of irreversible modulation in drug discovery
Start: 2024-10-16T09:00:00+01:00
End: 2024-10-17T17:45:00+01:00
Location: The Discovery Centre, Biomedical Campus, 1 Francis Crick Ave, Trumpington, Cambridge, CB2 0AA

Schedule

Wed Oct 16 2024 at 09:00 am to Thu Oct 17 2024 at 05:45 pm

UTC+01:00

Location

The Discovery Centre, Biomedical Campus, 1 Francis Crick Ave, Trumpington, Cambridge, CB2 0AA | Cambridge, EN

**Call for abstracts now open until 28 June 2024**
Irreversible covalent modulation is a crucial part of the drug discovery toolbox and is an important strategy for finding tractable equity against less druggable targets. However, understanding the binding kinetics, mechanistic PK/PD relationship and SAR of compounds is critical to success as is employing best practice in hit identification and lead optimisation.
Join us in Cambridge on 16-17 October 2024, where we will bring together established leaders and emerging investigators exploring the use of irreversible covalent modulators in drug discovery. Targeting of both cysteine and other amino acid residues will be considered as will in depth analysis of the kinetics of irreversible inhibition. Irreversible modulation as a strategy for targeted protein degradation and the identification of covalent chemical equity through proteomic approaches will also be covered.
Find out more and register: https://my.bps.ac.uk/events/details/?id=4166895c-c041-ee11-bdf3-6045bdd2c896