Dr. Lauren Woodie Lab Tour

In the Woodie Lab, we investigate the neurobiology of chrono-metabolic rhythms. We use surgical, genetic, and dietary rodent models to identify mistimed eating-sensitive neurons, disrupt their signaling, and measure the metabolic and behavioral outcomes arising from various interventions with the goal of discovering therapies for diseases exacerbated by chrono-disruption (i.e., jet lag and shift work).

To conduct these experiments, our lab space has the following:

• Dedicated surgical space to perform stereotaxic surgical injections in the mouse brain
• Fresh-tissue vibratome to slice the mouse brain and spinal cord for viewing under a microscope
• Preserved biological samples (e.g., fixed whole-brain samples, microscope slides of the brain sections)
• Temperature- and light-controlled incubator cabinet designed to house mice in a thermoneutral environment
• “Promethion” cage system that collects real-time behavioral and metabolic data from individual mouse cages: oxygen and CO2 respiration, body mass, locomotor activity, food and water intake

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