Borer Lecture: Greg Cartee, PhD
Schedule
Fri Nov 01 2024 at 03:00 pm to 04:00 pm
UTC-04:00Location
830 N. University Ave., Ann Arbor, MI, United States, Michigan 48109 | Ann Arbor, MI
Movement Science professor Greg Cartee is this year's Borer Lecture guest speaker. He will discuss, "Pursuing the Mechanisms for Improved Insulin Sensitivity after Exercise."Reception to follow. Open to the public.
RSVP for the in-person event: myumi.ch/Drmw4
Register for the Zoom simulcast: myumi.ch/jZDg4
We are grateful to Professor Emerita Katarina Borer and Dr. Paul Wenger for funding the Katarina T. Borer Lectureship in Exercise Endocrinology and Metabolism.
Abstract:
Type 2 diabetes (T2D), which afflicts more than 38 million Americans, can have major detrimental consequences on many aspects of health, physical function, and life-expectancy. A reduction in the ability of insulin to lower blood glucose levels (insulin resistance) is an essential defect in the pathology that underlies T2D. Nearly 100 million Americans have prediabetes, which is characterized by insulin resistance and an increased risk to develop T2D. Even in nondiabetic individuals, insulin resistance increases the risk for cardiovascular disease, cognitive dysfunction, and some cancers. Understanding the mechanisms regulating insulin-stimulated glucose uptake by skeletal muscle is important because skeletal muscle accounts for the largest portion of insulin-mediated glucose disposal. In 1982, it was conclusively demonstrated that one exercise session can lead to subsequently improved insulin-stimulated glucose uptake by skeletal muscle. In the intervening years, many studies have aimed to elucidate the mechanisms responsible for this important health benefit. After providing a brief summary of relevant research by others in both humans and preclinical animal models, my presentation will focus on my research group’s efforts related to this topic. I will discuss some of our discoveries related to exercise-induced improvement in insulin sensitivity, including: the potential roles for several key signaling proteins, sex-related similarities and differences in post-exercise insulin sensitivity, and the long-held belief that muscle glycogen accumulation (glycogen supercompensation) after exercise is crucial for the reversal of the enhanced insulin-stimulated glucose uptake by muscle.
