2024 Medicinal Chemistry Symposium: New Drugs on the Horizon

This meeting will be hosted by Bristol Myers Squibb in Cambridge, MA.

Registration is required and ends at 11:30 PM on Friday, October 11th, 2024.

Thursday – October 17th, 2024

Bristol Myers Squibb

250 Water St, Cambridge, MA 02141

3:00 pm Welcome

Raj Rajur, Medicinal Chemistry Program Chair

CreaGen, Woburn, MA

3:10 pm Introductory Remarks (Moderator)

Paul Scola

BMS, Cambridge, MA

3:15 pm – 4:00 pm Denise Grünenfelder, Ph.D.

BMS, Cambridge, MA

Title: “Discovery of BMS-986408: A dual inhibitor of Diacylglycerol kinases alpha and zeta for cancer therapy”

4:00 pm – 4:45 pm Ben Milgram, Ph.D.

Scorpion Therapeutics, Cambridge, MA

Title: “Discovery of STX-721, a Covalent, Potent, and Highly Mutant-Selective EGFR Exon20 Insertion Inhibitor for the Treatment of Non-Small-Cell Lung Cancer”

4:45 pm – 5:00 pm Break

5:00 pm – 5:45 pm Kevin J. Filipski, Ph.D.

Pfizer, Cambridge, MA

Title: “PF-07328948, the first BDK inhibitor/degrader clinical candidate as a treatment for heart failure”

5:45 pm – 6:30 pm Robin Fairhurst, Ph.D.

Novartis, Basel, CH

Title: “Discovery of NVP-DFF332 as an Inhibitor of the Transcription Factor Hypoxia-Inducible Factor-2ALPHA (HIF-2α)”

7:00 pm – 8:30 pm Dinner

NESACS Med Chem Organizing Committee: Mark Ashwell; Brian. Aquila; Blaise Lippa; Andrew Scholte; Peter Fuller; Michelle Lamb; Silvana Leit; Melissa Grenier-Davies; Paul Scola; Lauren Monovich; Jason Beiger; Paul Greenspan; Raj Rajur

The Board Meeting is tentatively scheduled from 4:30-5:30 PM.

PUBLIC IS INVITED

YOU MUST REGISTER IN ADVANCE TO ATTEND THE SYMPOSIUM.

If you will only attend the Symposium (3-6:30 pm), please select the free "meeting only" ticket.

If you will attend the Symposium and dinner or just the dinner, please select a dinner plus meeting ticket.

• Reservations should be made no later than 11:30 PM, Friday, October 11, 2024.

Directions and Parking information

Please use google map: 250 Water St, Cambridge, MA 02141

MBTA closest stop is Lechmere, Greenline.

There is no free parking. Paid parking is available at 211 Water Street, Cambridge MA 02141, directly across from the BMS entrance.

Registration or other questions? Please contact: Dr. Paul Scola by email at [email protected] or Raj Rajur; [email protected].

Host or Publisher The Northeastern Section of the American Chemical Society